Linkage of Susceptibility to Experimental Allergic Encephalomyelitis to the Major Histocompatibility Locus in the Rat

Major Susceptibility Locus on Chromosome 9 Encephalomyelitis in the Rat Identifies a Relapsing Experimental Autoimmune Genome-Wide Linkage Analysis of Chronic

Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis.

Multiple sclerosis (MS) and its animal model, myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (MOG-EAE), share a complex genetic predisposition with contributions from the major histocompatibility complex class II genes and many other genes. Linkage mapping in F(2) crosses between the susceptible DA rat strain and the resistant ACI or BN rat strains in vari...

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases.

Human autoimmune diseases are thought to develop through a complex combination of genetic and environmental factors. Genome-wide linkage searches of autoimmune and inflammatory/immune disorders have identified a large number of non-major histocompatibility complex loci that collectively contribute to disease susceptibility. A comparison was made of the linkage results from 23 published autoimmu...

Incidence of Histological and Clinical Signs of EAE in Lewis , BN , (

Experimental allergic encephalomyelitis (EAE) 1 has been widely studied as a possible experimental model for human demyelinative diseases, the two most common of which are multiple sclerosis and acute disseminated encephalomyelitis. EAE is also the only experimental autoimmune disease for which the exact amino acid sequence of an inciting molecule, basic protein of myelin, is known (1). Nearly ...

eae36, a locus on mouse chromosome 4, controls susceptibility to experimental allergic encephalomyelitis in older mice and mice immunized in the winter.

Genetic factors are believed to contribute to multiple sclerosis (MS) susceptibility; however, strong evidence implicating intrinsic and environmental factors in the etiopathogenesis of MS also exists. Susceptibility to experimental allergic encephalomyelitis (EAE), the principal animal model of MS, is also influenced by nongenetic factors, including age and season at immunization. This suggest...